Brain tumor patients experience more learning and memory problems when whole-brain radiation treatment (WBRT) is added to standard stereotactic radiosurgery (SRS), researchers have found.
SRS delivers narrowly focused beams of radiation to the tumor site.
The study included 58 patients with one to three newly diagnosed brain metastases who were randomly chosen to receive SRS alone (30 patients) or SRS plus WBRT (28 patients). However, the trial was halted early because there was a 96 percent probability that patients in the SRS/WBRT group were considerably more likely to experience declines in memory and function after four months than those receiving SRS alone.
After four months, there were four deaths (13 percent) in the patients who received SRS alone and eight deaths (29 percent) in the SRS/WBRT group, the study authors reported. After one year, 73 percent of patients in the SRS/WBRT group were recurrence-free, compared with 27 percent of patients who received SRS alone.
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SRS delivers narrowly focused beams of radiation to the tumor site.
The study included 58 patients with one to three newly diagnosed brain metastases who were randomly chosen to receive SRS alone (30 patients) or SRS plus WBRT (28 patients). However, the trial was halted early because there was a 96 percent probability that patients in the SRS/WBRT group were considerably more likely to experience declines in memory and function after four months than those receiving SRS alone.
After four months, there were four deaths (13 percent) in the patients who received SRS alone and eight deaths (29 percent) in the SRS/WBRT group, the study authors reported. After one year, 73 percent of patients in the SRS/WBRT group were recurrence-free, compared with 27 percent of patients who received SRS alone.
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